I no longer have a car, so I don't listen to This American Life in the car. When I'm at home, I'm usually either watching TV or reading, neither of which is conducive to listening to This American Life. I really like the show, but it just seems that I never want to just sit and listen to it.
But I've now found that I can put it on while I'm in the office on the weekend, especially when I'm doing relatively straightforward stuff. Cool.